منابع مشابه
Migraine meets membrane trafficking.
Having a drug that works clinically, but without a clear mechanism, is like having a key that can be tried on many doors—eventually one will open, but what will be found? The paper by Burstein and colleagues (1) in this issue of Cephalalgia describes an unexpected connection between migraine and membrane trafficking associated with mechanical pain. In an elegant series of experiments, they show...
متن کاملUbiquitin meets PIWI protein.
M IWI and PIWI-interacting RNA (piRNA), which binds to PIWI family members including MIWI, contribute to post-transcriptional regulation in spermiogenesis, however, their molecular functions had been unclear. Recently, Zhao and colleagues reported that loading of piRNA to MIWI leads to ubiquitin-proteasome mediated degradation in late spermatid and that this process is essential for the maturat...
متن کاملMembrane Trafficking: An Endosome Tether Meets a Rab and Collapses
Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition and facilitating short-range interactions required for fusion.
متن کاملThe neurotrophin receptor signaling endosome: Where trafficking meets signaling.
Neurons are the largest cells in the body and form subcellular compartments such as axons and dendrites. During both development and adulthood building blocks must be continually trafficked long distances to maintain the different regions of the neuron. Beyond building blocks, signaling complexes are also transported, allowing for example, axons to communicate with the soma. The critical roles ...
متن کاملA conserved heme redox and trafficking pathway for cofactor attachment
Thank you for submitting your manuscript for consideration by the EMBO Journal. I apologise for the delay in getting back to you with a decision but we have still not received the final report from the third referee despite several reminders and telephone calls. Since the other two reviewers seem to be in fair agreement, I would like to provide you with a preliminary decision on your manuscript...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2015
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2015.01.010